Abstract: In order to enhance flood control safety response capabilities in plateau regions under complex water inflow conditions of summer rainstorms combined with snowmelt, relying on digital twin technology and considering the operational needs of watershed flood control, this study investigated key technologies for the Zhongqu River Basin in Tibet. These include snowmelt-based flood forecasting, threshold comparison-based flood warning, critical channel-based flood scenario simulation, and highly customized flood control plans. A digital twin-based "Four Predictions" (forecasting, early warning, pre-simulation, and plan formulation) flood control system was developed for the Zhongqu River Basin. Research results demonstrate that by customizing flood control "Four Predictions" analytical models and constructing a digital twin platform system, precise mapping between physical and digital watershed elements can be achieved along with synchronized simulation of flood processes, significantly enhancing flood control safety assurance capabilities under complex water inflow conditions in plateau regions.